Selkis founded Messari in 2018, transforming it into a premier crypto analytics firm that secured over $35 million in Series B funding from investors including Point72, Brevan Howard Digital, and Coinbase Ventures, rivaling legacy platforms like Bloomberg. He organizes the influential Mainnet conference in New York, securing high-profile interviews with crypto influencers and political figures to bridge digital assets with mainstream finance. In July 2024, after politically charged X posts supporting Donald Trump, he briefly stepped back from CEO duties but resumed leadership, recently authoring the expansive 275-page Crypto Theses 2026 report previewing DePIN, AI integration, and consumer adoption surges. Messari under Selkis declared war on the SEC in 2024, vowing legal action against what it calls a corrupt regulator. No documented connections tie him to Miami or South Florida; his activities revolve around New York and national crypto policy arenas.